Waking up dormant HIV <a href="http://www.physorg.com/news156424517.html">http://www.physorg.com/news156424517.html</a><br /><font size="2"><br />March 16th, 2009 <!-- Main --><!-- <div id="news-main"> --><span class="newsimg" itxtvisited="1"></span><!-- google_ad_section_start --></font> <p class="clear" itxtvisited="1"><strong itxtvisited="1">HAART (highly active anti-retroviral therapy) has emerged as an extremely effective HIV treatment that keeps virus levels almost undetectable; however, HAART can never truly eradicate the virus as some HIV always remains dormant in cells. But, a chemical called suberoylanilide hydroxamic acid (SAHA), recently approved as a leukemia drug, has now been shown to 'turn on' latent HIV, making it an attractive candidate to weed out the hidden virus that HAART misses.</strong> <br /></p> <p itxtvisited="1">Matija Peterlin at UCSF and colleagues had previously identified another chemical called HMBA that could activate latent <a class="textTag" href="http://www.physorg.com/tags/hiv/" rel="tag"><font color="#0e3266">HIV</font></a>, but the risk of several toxic side effects made HMBA clinically non-viable. However, the chemically similar SAHA had received FDA approval, making it a potentially safer alternate. </p> <p itxtvisited="1">So, the researchers examined whether SAHA had any effect on HIV latency. They found that SAHA could indeed stimulate <a class="textTag" href="http://www.physorg.com/tags/latent+hiv/" rel="tag"><font color="#0e3266">latent HIV</font></a> to begin replicating, which exposes the infected cell to HAART drugs. SAHA could activate HIV in both laboratory <a class="textTag" href="http://www.physorg.com/tags/cells/" rel="tag"><font color="#0e3266">cells</font></a> as well as from blood samples taken from HIV patients on antiretroviral therapy. Importantly, this successful activation was achieved using clinical doses of SAHA, suggesting toxicity will not be a problem.<br /><br />Dịch đoạn quan trọng nhất (Mình chỉ dịch theo ý )<br /><br /><strong>HAART như là một phương pháp điệu trị Hiv rất hiệu quả giữ số lượng virus ở mức dường như không thễ phát hiện, tuy nhiên, Haart không thễ diệt hoàn toàn virus vì một số virus ở trạng thái ẩn trong tế bào. Nhưng một chất được gọi là suberoylanilide hydroxamic acid (SAHA) được phê chuẫn để điều trị Leukemia, đã được chứng minh có khả năng&nbsp;"khởi động" những Virus đang ẫn trong tế bào này. Điều đó đã làm cho SAHA trở&nbsp;thành một 'ứng cử viên' hấp dẫn để loại trừ những virus 'Ẩn' ma HAART không trị được.<br /><br />...<br /><br /><img src="/images/emotions/smile.gif" /></strong></p>