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[email protected]</td></tr> <tr><td class="label" nowrap="nowrap">Tiêu đề:</td><td> Chua khoi HIV - thuc tien va hoai nghi</td></tr> <tr><td class="label" nowrap="nowrap">Ngày:</td><td> Fri, 15 Jun 2007 16:34:10 +0700</td></tr> </tbody></table> <form name="frmAddAddrs" action="http://address.mail.yahoo.com/yab/vn?v=YM&.rand=75359&A=m&simp=1" method="post"> <input name="fn" value="
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[email protected]" type="hidden"> <input name=".done" value="http://vn.f354.mail.yahoo.com/ym/ShowLetter?MsgId=5390_0_19960_1550_4956_0_9006_15258_1678274612_oSOYkYn4Ur6Rg9OuJfSMZ6xrSp6kYm3dALcYeOzUdoX1M.lM0Da3KcbYfe4kq7zL1OBrK3WDkVqf3WJaczI5bzoAmmdmryH7gnMuAUq.IJv2SpZC.KSWjS6e2xQcVtORZfMoKA5X2F3OAQIVrc67OQbfwyHL_V0xFwzVxDipi7w-&order=down&inc=&sort=date&view=a&head=b&box=@B@Bulk&YY=37977" type="hidden"> </form> <!-- type = text --> <p>JVnet xin gioi thieu voi cac ban bai bao thu vi nay, mo ta nhung dien bien moi nhat cua mot van de rat quan trong trong dieu tri HIV - lieu co kha nang chua khoi HIV duoc khong. </p> <p>JVnet co ban tieng Anh cua bai bao goc tren Tap chi Benh Truyen nhiem cua tac gia Chun. Ban nao quan tam co the gui email cho JVnet. Jvnet se gui bai den cho ban. </p> <p>JVnet<font color="#000080"> </font></p> <p>**********<font color="#000080"> </font></p> <p>CHUA KHOI HIV? THUC TIEN VA HOAI NGHI<font color="#000080"> </font></p><strong> </strong><p><strong>Michael Carter</strong>, 17/5/2007<font color="#000080"> </font></p> <p>Trong mot bai dang tren so ra ngay 15/6/2007 cua Tap chi Benh Truyen nhiem (Journal of Infectious Diseases), cac nha nghien cuu o My gan day da dua ra nhan xet rang neu bat dau dieu tri thuoc khang virus ngay sau khi nhiem HIV thi co the loai tru hoan toan virus nay ra khoi co the sau khoang 8 nam. Nghien cuu cua ho duoc thuc hien tren 7 benh nhan.Ho nhan thay rang luong te bao CD4 bi nhiem HIV va o trang thai khong hoat dong cu sau 5 thang dieu tri bang thuoc khang virus se giam di mot nua. Cac nha nghien cuu nay uoc tinh la sau khoang thoi gian trung binh la 7,7 nam thi tat ca cac te bao CD4 co nhiem HIV va o trang thai khong hoat dong se bi loai tru het. </p> <p>Nhung cac tac gia cua mot bai phan tich dang kem theo bai bao ke tren thi lai to ra hoai nghi. Ho chi ra rang 4 trong so 7 benh nhan duoc nghien cuu co ty le phan huy virus cham hon, va ho cung goi y rang chi can mot vai te bao co nhiem HIV con ton tai cung du de lam moi cho tinh trang nhiem HIV tro lai neu ngung dieu tri bang thuoc khang virus. Cac tac gia cua bai phan tich nay cung luu y rang co kha nang la HIV co the ton tai dai dang trong cac te bao khong phai la CD4, hoac la trong cac mo cua co the. </p> <p>Cac chien luoc dieu tri HIV hien tai khong the loai tru hoan toan HIV khoi co the. Ly do cua hien tuong nay la do su ton tai dai dang cua nhung diem chua virus, dac biet la cac te bao CD4 nhiem HIV va o trang thai khong hoat dong. <br /><br />Chinh vi biet rang mot khi cac te bao o trang thai khong hoat dong va nhiem HIV nay con ton tai thi viec loai tru hoan toan HIV la khong the xay ra, cac nha nghien cuu da co gang xac dinh thoi gian ban huy (thoi gian mot nua bi chet) cua cac diem chua virus nay. Ho hy vong rang thong tin nay se co the giup dua ra cac chien luoc nham loai tru hoan toan HIV khoi co the, bang cach su dung cac thuoc khang virus moi hon va hieu qua hon, nhu cac thuoc ngan chan su ket noi cac thanh phan cua virus (integrase inhibitor). </p> <p>Trong nghien cuu nay, cac nha khoa hoc da theo doi mot cach ti mi 7 benh nhan da bat dau dieu tri thuoc khang virus ngay sau khi nhiem HIV mot thoi gian rat ngan, trung binh la 7 thang sau khi co bieu hien nhiem virus cap tinh va duoc xac dinh la nhiem HIV. Tat ca deu duoc dieu tri bang it nhat la mot loai thuoc chan ket noi cac thanh phan de hinh thanh virus va hai loai chan men sao chep nguoc (NRT). </p> <p>Cac xet nghiem cho thay cac diem chua cac te bao nhiem virus o tat ca 7 benh nhan deu bi huy va cac nha nghien cuu tinh toan rang cu 4,6 thang thi so diem chua nay lai bi huy di mot nua. Voi gia thuyet la trong co the mot nguoi co HIV co 1 trieu diem chua nhu vay thi sau khoang thoi gian trung binh la 7,7 nam tat ca cac diem chua nay se bi huy het. <br /><br />Cac nha nghien cuu viet "Nghien cuu nay chung minh rang trong nhung benh nhan dieu tri bang thuoc khang virus tu khi moi nhiem HIV, hien tuong tieu huy diem chua virus trong cac te bao CD4 khong hoat dong la thuc su dien ra". </p> <p>Ho tin tuong rang ket qua nghien cuu cua ho co the co tac dong quan trong tren lam sang, dac biet la "doi voi viec xay dung cac chien luoc tri lieu trong tuong lai nham loai tru HIV. Mac du hien tuong tiep tuc nhiem HIV la khong the loai tru o cac benh nhan bat dau dieu tri trong giai doan dau nhiem HIV, viec tim kiem cac bang chung ve kha nang loai tru hoan toan HIV trong co the nhung nguoi da dieu tri trong mot thoi gian nhat dinh (8 nam) co y nghia quan trong". <br /><br />Cac nha nghien cuu du dinh se kiem dinh gia thuyet nay tren mot mau lon. Ho cung du dinh se su dung thuoc raltegravir chan ket noi cac thanh phan cua virus cua hang Merck (Isentress) va thuoc chan bom enfuvirtide cua hang Roche (Fuzeon) tren cac benh nhan ve sau, nham tang toc do giam luong virus trong giai doan dau dieu tri, voi hy vong rang dieu do se lam giam tong luong te bao bi nhiem va do do rut ngan qua trinh dieu tri can thiet cho toan bo cac o chua nay bi huy hoai. </p><font color="#000080"> </font><p><font color="#000080"><br /></font>Cac tac gia cua bai bao khac thi lai to ra than trong hon. Ho luu y rang "phan tich so lieu sau hon thi se nhan thay rang o it nhat la 4 benh nhan hien tuong huy hoai virus dien ra cham hon". Ho cung nhan manh rang su ton tai dai dang cua "vai te bao nhiem virus... cung co the du de lam cho tinh trang nhiem bung phat tro lai". Them vao do "cung co kha nang la HIV co the ton tai trong cac te bao khong phai la CD4 du la rat hiem hoac cac te bao (CD4) khong hoat dong ma luu thong trong mau khong dai dien duoc cho cac te bao khong hoat dong nam trong cac mo". </p> <p>Cac tac gia nay cung trich dan cac nghien cuu ghi nhan su hien dien cua HIV trong dich nao tuy va trong he thong than kinh trung uong, cung nhu su ton tai dai dang cua HIV trong cac to chuc lympho trong ruot. </p><font color="#000080"> </font><p><font color="#000080"><br /></font>Dieu tri bang thuoc khang virus dong nghia voi viec nhung nguoi co HIV co tien luong binh thuong. Do do, cac tac gia tin rang de dat duoc nhung tien bo vuot bac so voi cac phuong phap dieu tri hien co la rat kho khan. Viec dieu tri HIV dang ngay cang tro nen hieu qua nhung khong phai voi cai gia la lam tang them su bat tien hoac doc tinh. </p><font color="#000080"> </font><p><font color="#000080"><br /></font><strong>Tai lieu tham khao</strong><font color="#000080"> </font></p> <p><font color="#000080"><br /></font>Chun T-W et al. <i>Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: implications for eradication of virus</i>. J Infect Dis 195 (online edition), 2007. <br /><br />Margolis DM et al. <i>Eliminating persistent HIV infection: getting to the end of the rainbow</i>. J Infect Dis 195 (online edition), 2007. </p> *****************************<br />JVnet la ban tin hang ngay bang tieng Anh va tieng Viet, mien phi cho tat ca moi nguoi quan tam den HIV/AIDS o Vietnam va tren the gioi. <br />JVnet do Bac si Jamie Uhrig sang lap, tu nam 2002 den nay do Vien Nghien cuu Phat trien Xa hoi quan ly. JVnet duoc su ho tro ve tai chinh cua Quy Ford.<br />Tuy nhien, moi thong tin dua tren JVnet la thuoc trach nhiem cua nhom bien tap JVnet, khong lien quan gi den Quy Ford. <br />Neu ban muon lien lac voi JVnet de dang ky nhan tin, ngung nhan tin, gui bai hoac gop y, xin gui email ve dia chi <a rel="nofollow">
[email protected]</a><font face="Arial" size="2"><br /></font>De doc duoc tin tieng Viet co dau, xin vui long vao website: <a rel="nofollow">http://www.isds.org.vn/jvnet-news.asp</a><font face="Arial" size="2"><br /></font>JVnet rat vui mung duoc lam dien dan de cac ban chia se thong tin, va mong nhan duoc y kien gop y cua cac ban.
